Rupatadine is a second-generation antihistamine primarily used for the management of allergic conditions such as allergic rhinitis and chronic urticaria. It exerts its therapeutic effects by selectively blocking H₁ histamine receptors, thereby reducing symptoms like sneezing, itching, nasal congestion, and hives. In addition, rupatadine inhibits platelet-activating factor (PAF), contributing anti-inflammatory and anti-allergic benefits. Compared to first-generation antihistamines, it causes minimal sedation, making it suitable for daytime use. Rupatadine is generally well tolerated, has a favorable safety profile, and is conveniently administered once daily, offering effective relief from allergy symptoms over a 24-hour period.
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