Category
Lopinavir
CAS Number
STD - 192725-17-0 : IMP - A - 192726-05-9 : IMP - B - NA : IMP - C - NA : IMP - F - NA : IMP - G - NA : IMP - I : IMP - N - 1798014-18-2 : IMP - Q - 667904-94-1 : IMP - R - 943250-66-6: IMP - S -943250-65-5: IMP - T - 1797024-56-6 ;
Molecular Formula
STD-C37H48N4O5:IMP-A-C27H38N4O3:IMP-B-C28H38N4O4:IMP-C-C36H52N6O5:IMP-F-C29H34N2O4:IMP-G-C30H36N2O4:IMP-I-C37H48N4O5:IMP-N-C37H48N4O5:IMP-Q-C38H44N2O5:IMP-R-C47H58N4O7:IMP-S-C47H58N4O7:IMP-T-C57H66N4O7
Molecular Weight
STD-628.81 g/mol:IMP-A-466.63 g/mol:IMP-B -494.64 g/mol:IMP-C-648.84 g/mol:IMP-F-474.59 g/mol:IMP-G-488.62 g/mol:IMP-I-628.8 g/mol:IMP-N -628.80 g/mol:IMP-Q-608.77 g/mol:IMP-R-790.99 g/mol:IMP-S-790.99 g/mol:IMP-T-919.16 g/mol :
Synonym

Lopinavir - (alphaS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide;  (2S)-N-[(2S,4S,5S)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide ;

Lopinavir EP Impurity - A - Lopinavir Free Amine (USP) ; (2S)-N-[(1S,3S,4S)-1-Benzyl-4-amino-3-hydroxy-5-phenylpentyl]-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanamide ; (2S)-N-[(2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide; (S)-N-[(2S,4S,5S)-5-Amino-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide;

Lopinavir EP Impurity - B - (2S)-N-[(1S,3S,4S)-1-benzyl-4-(formylamino)-3-hydroxy5-phenylpentyl]-3-methyl-2-[2-oxotetrahydropyrimidin1(2H)-yl]butanamide;Lopinavir N-formylaminoalcohol ; (S)-N-[(2S,4S,5S)-5-Formamido-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanamide ;

Lopinavir EP Impurity - C - (2R)-N-[(1S,2S,4S)-1-benzyl-2-hydroxy-4-[[(2S)-3-methyl2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanoyl]amino]-5-phenylpentyl]-3-methyl-2-[2-oxotetrahydropyrimidin1(2H)-yl]butanamide ; (S)-N-((2S,4S,5S)-4-hydroxy-5-((R)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamido)-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide ;

Lopinavir EP Impurity - F - N-[(1S,2S,4S)-1-benzyl-4-(formylamino)-2-hydroxy-5-phenylpentyl]-2-(2,6-dimethylphenoxy)acetamide; Lopinavir N-Formylphenoxyacetamide (USP) ;

Lopinavir EP Impurity - G - N-[(1S,2S,4S)-(4-acetylamino)-1-benzyl-2-hydroxy-5- phenylpentyl]-2-(2,6-dimethylphenoxy)acetamide ;N-((2S,3S,5S)-5-acetamido-3-hydroxy-1,6-diphenylhexan-2-yl)-2-(2,6-dimethylphenoxy)acetamide ; LopinavirN-Acetylphenoxyacetamide(USP);

Lopinavir EP Impurity - I - (2S)-N-[(1S,2S,4S)-1-benzyl-4-[[2-(2,6-dimethylphenoxy)-acetyl]amino]-2-hydroxy-5-phenylpentyl]-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanamide ; Lopinavir Isomer / Isolopinavir ;

Lopinavir EP Impurity - N - (2S)-N-[(1S,3R,4S)-1-benzyl-4-[[2-(2,6-dimethylphenoxy)-acetyl]amino]-3-hydroxy-5-phenylpentyl]-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanamide ; (S)-N-{(2S,4R,5S)-5-[2-(2,6-Dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl}-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanamide (as per USP);  Lopinavir (4R)-Epimer (USP) ;

Lopinavir EP Impurity - Q - N-[(1S,2S,4S)-1-benzyl-4-[[2-(2,6-dimethylphenoxy)-acetyl]amino]-2-hydroxy-5-phenylpentyl]-2-(2,6-dimethylphenoxy)acetamide ; N,N'-((2S,3S,5S)-3-hydroxy-1,6-diphenylhexane-2,5-diyl)bis(2-(2,6-dimethylphenoxy)acetamide) ; 

Lopinavir EP Impurity - R - (2S)-N-[(1S,3S,4S)-1-benzyl-4-[[2-(2,6-dimethylphenoxy)- acetyl]amino]-3-hydroxy-5-phenylpentyl]- 2-[3-[2-(2,6- dimethylphenoxy)acetyl]-2-oxotetrahydropyrimidin1(2H)-yl]-3-methylbutanamide;

Lopinavir EP Impurity - S - (1S,3S)-1-[(1S)-1-[[2-(2,6-dimethylphenoxy)acetyl]-amino]-2-phenylethyl]-3-[[(2S)-3-methyl-2-[2-oxotetrahydropyrimidin-1(2H)-yl]butanoyl]amino]-4-phenylbutyl 2-(2,6-dimethylphenoxy)acetate ;

Lopinavir EP Impurity - T - N,N'-bis[(1S,3S,4S)-1-benzyl-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenylpentyl]urea ; N,N'-((2S,2'S,3S,3'S,5S,5'S)-(Carbonylbis(azanediyl))bis(3-hydroxy-1,6-diphenylhexane-5,2-diyl))bis(2-(2,6-dimethylphenoxy)acetamide); 

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Lopinavir can be used in system suitability tests in chromatographic analysis to verify that the HPLC system is functioning correctly. In Comparative Retention Studies (CRS), it serves as a reference to ensure consistent retention times, peak resolution, and reproducibility of the analytical method.