Sodium amide

Sodium amide (CAS No. 7782-92-5, molecular formula  NaNH2, molecular weight 39.01 g/mol) is a highly reactive inorganic compound widely used in organic synthesis, pharmaceutical manufacturing, and industrial chemical processes. Known for its strong basicity, sodium amide functions as a powerful deprotonating agent, particularly in the formation of acetylide anions from terminal alkynes, and is extensively applied in nucleophilic substitution, elimination, cyclization, and condensation reactions. It plays a critical role in the synthesis of heterocyclic compounds, active pharmaceutical intermediates (APIs), agrochemicals, dyes, and fine chemicals, making it an essential reagent in both laboratory research and large-scale production. Due to its efficiency in amide formation, polymer modification, and specialty chemical manufacturing, sodium amide remains a preferred base in demanding synthetic applications. Manufactured and supplied by reliable chemical manufacturers and global suppliers, it is available in laboratory and bulk quantities with certificates of analysis (CoA), safety documentation, and technical support for R&D, pilot-scale, and commercial production.