Zofenopril is an angiotensin-converting enzyme (ACE) inhibitor used to treat hypertension and heart failure by blocking the formation of angiotensin II, leading to vasodilation and reduced blood pressure. It was developed in the 1980s as part of research into sulfhydryl-containing ACE inhibitors with improved cardioprotective and antioxidant properties compared to earlier drugs, and it was later introduced into clinical use in several countries in the 1990s, becoming valued for its effectiveness in cardiovascular disease management and post-myocardial infarction protection.
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