Pancuronium bromide is a long-acting, non-depolarizing neuromuscular blocker used to induce skeletal muscle relaxation during surgery, mechanical ventilation, and critical care procedures. It works by competitively inhibiting acetylcholine at nicotinic receptors of the neuromuscular junction, preventing muscle contraction. Developed in the 1960s as part of the aminosteroid class, pancuronium quickly became popular for its potency, predictable onset, and long duration, making it ideal for lengthy surgical procedures. While generally effective, its use requires careful monitoring due to potential cardiovascular effects, such as mild increases in heart rate and blood pressure. Over time, shorter-acting alternatives have emerged, but pancuronium remains a valuable option in anesthesia and intensive care settings.
