Catégorie
Cefotaxime
Numéro CAS
Cefotaxime STD- 63527-52-6 : Imp A - 65052-63-3: Imp B - 66340-28-1 : Imp C - 66403-32-5 : Imp E - 66340-33-8 :Imp - F
Formule moléculaire
Cefotaxime STD- C16H17N5O7S2 : Imp A - C14H15N5O5S2 : Imp B - C14H15N5O6S2 : Imp - C - C17H17N5O8S2 : Imp -E :Imp - F
Masse moléculaire
Cefotaxime STD- 455.47 g/mol : Imp A -397.4 g/mol : Imp B - 413.4 g/mol : Imp - C - : Imp -E :Imp - F
Synonyme

Cefotaxime - (6R,7R,Z)-3-(Acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;

Cefotaxime EP Impurity A - (6R,7R)-7-[[(2Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ;

Cefotaxime EP Impurity B - (6R,7R)-7-[[(2Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ;

Cefotaxime EP Impurity C - (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-2-[2-(formylamino)thiazol-4-yl]-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ; 

Cefotaxime EP Impurity E - (5aR,6R)-6-[[(2Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetyl]amino]-5a,6-dihydro-3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazine-1,7(4H)-dione ;

Cefotaxime EP Impurity F - (6R,7R)-3-[(Acetyloxy)methyl]-7-[[(2Z)-2-[2-[[[(6R,7R)-7-[[(2Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-yl]methyl]amino]thiazol-4-yl]-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;

 

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Purity:

Above - 95.0%

Technical Data:

We will provide complete documentation support for every Standard Material. All analytical reports such as ¹H NMR, ¹³C NMR, Mass, FT-IR, HPLC Purity/GC Purity/QNMR Purity, Water content by KF/ Loss on Drying/TGA (Thermo-gravimetric Analysis). Certificate of Analysis with potency report. Each Standard Material SER (Structure Elucidation Report) with NMR, Mass, IR spectral interpretation. This whole analytical document can be included in eCTD, ANDA, DMF submissions to regulatory agencies.

Cefotaxime plasma levels are measured to determine peak concentration (Cmax) and timing for optimizing dosing in patients. It helps ensure therapeutic effectiveness while minimizing toxicity in clinical studies or patient monitoring.